Researchers are suggesting there is a new genetic form of Alzheimer’s.

In the Genes

The Story

Researchers are suggesting there is a new genetic form of Alzheimer’s.

Tell me more.

Yesterday, a new study revealed that an estimated 1 in 6 cases of Alzheimer’s could be inherited. It focused on a gene variant called APOE4, which has long been considered to elevate the risk of developing the disease. By analyzing data from over 500 people with two copies of the gene, the researchers found that APOE4 could be considered an underlying cause. The study also found that many of the patients started developing symptoms by age 65, younger than most people without two copies of the gene variant. The findings are turning heads because the majority of Alzheimer’s cases reportedly don’t have a known cause.

What does this mean?

This new research could lead to hundreds of thousands of people being diagnosed before the onset of symptoms. It could also spur new studies and clinical trials, potentially influencing treatment options that target the specific APOE4 gene. Still, researchers say that not everyone who has two copies of the gene will develop Alzheimer’s — something that scientists need to look into to understand why that's the case. The study’s authors also note that further research is needed to see how the gene variant affects diverse populations.

theSkimm

Nearly 7 million Americans live with Alzheimer’s. Now, new evidence suggests that there may be an inherited subset of the disease that could be prevented or delayed with more research.

Where people are on watch…

Rafah. This morning, Israel seized control of the southern Gaza city's border crossing. This comes after they began striking targets in the southern Gaza city, with Palestinian hospital officials saying several people were killed. Israel began an attack on eastern Rafah yesterday, which came less than a day after Hamas accepted an Egyptian-Qatari cease-fire proposal and after Israel ordered about 100,000 Palestinians to evacuate, indicating that an offensive could be imminent. Israeli PM Benjamin Netanyahu’s office said that although Hamas’s proposal is “far” from meeting the country’s demands, it would still continue talks to “exhaust the possibility of reaching an agreement.” His office also said that Israel will proceed with its operation in Rafah to release hostages and destroy Hamas.

Who’s going to have to pay up again…

Former President Trump. Yesterday, the judge overseeing Trump’s hush money trial fined the former president another $1,000 for once again violating a gag order. It marks the second time the judge held him in contempt of court since the trial got underway three weeks ago. This time, Trump violated the gag order — which bars him from attacking witnesses, prosecutors, court staff or their families in the case — by saying the jury was “95% Democrats” and picked too quickly. The judge warned that Trump could face jail time, potentially a maximum of 30 days, if there were more gag order violations.

Where florals were actually groundbreaking…

The Met Gala. Yesterday, celebrities ascended the Metropolitan Museum of Art’s steps for this year’s “The Garden of Time” theme. Gigi Hadid and Nicki Minaj literally blossomed. Lana Del Rey branched out. Cardi B and Tyla got carried away. Zendaya showed off not one, but two looks. There were butterflies, fairy ears, and AI fakes. Oh and a wet T-shirt dress. Notably missing were Rihanna and Blake Lively. Meanwhile, NYPD officers arrested several pro-Palestinian protesters near the event.

Why Boeing took an L yesterday...

Another investigation and a scrubbed launch to space.

What some people might not be sweating...

A $40,000 per year gym membership.

Who’s stepping into his shoe game...

Jack Harlow.

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